2. Neuronal Signaling
  3. Sigma Receptor
  4. Sigma ligand-1

Sigma ligand-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 has a Ki of 4000 nM at the dopamine D2 receptor.

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Sigma ligand-1

Sigma ligand-1 Chemische Struktur

CAS. Nr. : 139652-01-0

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10 mM * 1 mL in DMSO
ready for reconstitution
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Sigma ligand-1 Related Antibodies

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Beschreibung

Sigma ligand-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma ligand-1 has a Ki of 4000 nM at the dopamine D2 receptor[1].

IC50 & Target

IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1]

Ki: 4000 nM (Dopamine D2 receptor)[1]
In Vivo

Administration of Sigma ligand-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma ligand-1 and its structural analogues have the potential antipsychotic activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

435.56

Formel

C27H33NO4
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C)=C(C2=CC=CC=C2)OC3=CC=C(OCCCCCCN4CCC(O)CC4)C=C13
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (229.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2959 mL 11.4795 mL 22.9590 mL
5 mM 0.4592 mL 2.2959 mL 4.5918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2959 mL 11.4795 mL 22.9589 mL 57.3974 mL
5 mM 0.4592 mL 2.2959 mL 4.5918 mL 11.4795 mL
10 mM 0.2296 mL 1.1479 mL 2.2959 mL 5.7397 mL
15 mM 0.1531 mL 0.7653 mL 1.5306 mL 3.8265 mL
20 mM 0.1148 mL 0.5740 mL 1.1479 mL 2.8699 mL
25 mM 0.0918 mL 0.4592 mL 0.9184 mL 2.2959 mL
30 mM 0.0765 mL 0.3826 mL 0.7653 mL 1.9132 mL
40 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4349 mL
50 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1479 mL
60 mM 0.0383 mL 0.1913 mL 0.3826 mL 0.9566 mL
80 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7175 mL
100 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5740 mL
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Sigma ligand-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sigma ligand-1139652-01-0Sigma ligand1Sigma ligand 1Sigma Receptorsigma receptorDTG sitePPP sitedopamine D2Inhibitorinhibitorinhibit

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